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Little Pharm Born

Big Pharm Failed, but EECS Saves Day
1/15/2016 10:18 AM EST
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PacJac
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Animal Testing is Unreliable
PacJac   1/31/2016 6:09:23 AM
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The following applies to pharmacological/medical/beauty products, etc.:  Since animals are nothing like us physically, biologically, psychologically, physiologically, etc., results of animal experimentation simply lead us in the wrong direction; in other words the tests are fundamentally flawed. People die because we rely on these results. There are newer, more reliable ways of testing that do not involve animals. Animals experience daily horrors such as cutting, burning, poisoning, death, and other barbaric acts.

Testing on animals will not prove that chemicals, ingredients, medications, etc., are safe for human beings due to the documented differences between species and because animals are given unrealistically high doses during experiments.  The U.S. Food and Drug Administration (FDA) has acknowledged that 92 percent of all drugs that test safe and effective in animals are found to be either unsafe or ineffective in humans.  It is not just the welfare of animals that we are concerned about, it is the fact, as I previously stated, that when we rely on animal testing, it is flawed and people die.  Although there are many non-animal methods of testing, we need to begin investing in more alternatives.

Rather than using live animals, for instance, combat trauma training courses can be taught using any of a variety of realistic, high-fidelity medical simulators.  For example, the Cut Suit, by Strategic Operations, Inc.  Compared to live tissue training, the Cut Suit comes closer to replicating the treatment of a human casualty.  Further, the Cut Suit can teach extremity tourniquet application, extremity arterial hemorrhage clamping, surgical incisions to the thoracic and abdominal cavity, hemorrhage control of organ structure, and suturing or stapling of organs and skin.

Another is the Maryland-based Operative Experience, Inc.  Not long ago, one highly regarded battlefield trauma expert and Uniformed Services University professor of surgery stated about Operative Experience's devices that it is "as close to human tissue as anything I've ever seen...[T]hese models are like nothing else out there...Combined with a curriculum, they have the capacity to revolutionize training".

I urge all of you to find out more for yourselves by going to any of the following websites for more information:  The first is Physicians Committee for Responsible Medicine at www.pcrm.org     www.ad-international.org/adi_usa/     www.aavs.org         www.navs.org     www.neavs.org

resistion
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Re: then Little "Pharm" doesn't understand quality engineering
resistion   1/18/2016 8:39:34 PM
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There has already been a move away from animals in cosmetics testing, but they involve other techniques simulating human response. I guess software can be used for the analysis, but a software-only approach doesn't make sense.

boblespam
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Re: then Little "Pharm" doesn't understand quality engineering
boblespam   1/18/2016 11:34:29 AM
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Last week a clinical test on humans went bad in France, one died and 5 are still suffering neurological damage. The tested drug is supposed to cure pain and anxiety, it passed animal trials.

This kind of software should be used in parallel with animal trials to reduce this kind of inacceptable risk.

MWagner_MA
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Re: then Little "Pharm" doesn't understand quality engineering
MWagner_MA   1/18/2016 10:33:47 AM
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You never know - the "pull" of people's faith in software is suprising to me at times.  Remember when there was talk about people basing a satelite design on a cell phone as a controller?

R_Colin_Johnson
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Re: then Little "Pharm" doesn't understand quality engineering
R_Colin_Johnson   1/18/2016 10:26:24 AM
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Nearly everyone would agree with the need for animal testing except Peta and their legions of followers who have already gotten animal testing on cosmetics virtually banned. Thanks for your, probably majority, opinion.

WLippitt
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Re: then Little "Pharm" doesn't understand quality engineering
WLippitt   1/18/2016 8:56:31 AM
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 Would it make sense to take several randomly selected trials with animal test results and compare them against their SW results?

MWagner_MA
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then Little "Pharm" doesn't understand quality engineering
MWagner_MA   1/18/2016 7:27:02 AM
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Evidently this group's quality department hs been asleep.  When we are working with a new vendor, we perform 100% inspection until the vendor PROVES that they can deliver nearly 100% of the time without incident.  This continues for about a year.  This approach should require BOTH animal and software simulation to prove and provide data it is just as effective.  What, they want us to just TRUST that the software is good.  Are you kidding me?  With this much money at stake.

sw guy
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Re: reliability
sw guy   1/18/2016 7:10:08 AM
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While I agree that such software should not be used without good guaranties, there is no need for sofware in the loop to get fatalities

R_Colin_Johnson
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Re: Little Pharm Trumps Big Pharm
R_Colin_Johnson   1/17/2016 4:28:11 PM
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Yes Big Pharm can but they don't want Small Pharm to compete with them because they won't be able to charge the overpriced prices they do now, not to mention the Big Money kickbacks they pay directly to doctors for prescribing their overpriced pills.

Ratgebber
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Re: Little Pharm Trumps Big Pharm
Ratgebber   1/17/2016 3:55:25 PM
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compare to the Virtual Fab technology that practically speaking fell through the cracks and maybe by design of Big Chip... Can't Big Pharma make use of the same chocking mechanism? Let's hope so... 

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