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Dr. Phil
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re: Researchers say carbon-based platform beats silicon for detection
Dr. Phil   7/27/2010 7:55:21 PM
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Colin, Don't know the current state of, but the base pair detection is key especially if speed comes to the table. I am M.D. and RF Engineer and am familiar with the existing equipment in general, which is doing auto sequencing since the Human Genome Project started. One of the primary scientists in the HGP actually designed the equipment which is currently used, as best as I remember. We are certainly headed for a hand held device to provide DNA ID in the field one day..I think. Electro-phoresis..is well known..and if its a matter of fine tuning an amplifiers sensibility..IBM may be real close. It still bowls me over to see how far we have come with DNA since Dr's Watson and Crick. just 4 little base pairs...repeated over and over again in a ballet of a million steps..or so. Yet we are all so unique..sometimes due to just a one base pair "oops" along the way. Phillips

R_Colin_Johnson
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re: Researchers say carbon-based platform beats silicon for detection
R_Colin_Johnson   7/27/2010 1:12:10 AM
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Any medical electronics experts out there know the state of personal DNA sequencing? I know that IBM has an effort to pull DNA strands through a nanopore and use a transistor to sense each base electrically as they pass through the pore. That sounds similar to this research at the University of Pennsylvania--which makes me think that sequencing an individual's DNA--which is IBM's professed aim--might be underway at other electronics labs too. Any medical electronics experts out there know the state of personal DNA sequencing?



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As data rates begin to move beyond 25 Gbps channels, new problems arise. Getting to 50 Gbps channels might not be possible with the traditional NRZ (2-level) signaling. PAM4 lets data rates double with only a small increase in channel bandwidth by sending two bits per symbol. But, it brings new measurement and analysis problems. Signal integrity sage Ransom Stephens will explain how PAM4 differs from NRZ and what to expect in design, measurement, and signal analysis.

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