Obama has been a disaster for business. He's taken a very hostile attitude, and businesses have responded by not investing in the US. He passed the Healthcare scam that raise the cost of doing business, and will sooner or later cause tax increases to insure those who aren't currently. He's allowing a massive tax increase to occur in January.
I fall back on an old adage. You can't be pro-jobs and anti-business. However, he's been very anti-business. Now one could argue, and I would agree, that there needs to be tightening of rules in the financial sector and the housing market, but that should have been straight forward to do. It should have been little more than a minor course correction to prevent what happened 2 years ago from repeating. With the bash business rhetoric, businesses have responded accordingly, and done nothing out of fear of uncertainty. QED.
Yes Intel is more patriotic that other companies, but even Intel isn't immune to US economic policy. I'm sure their recent decision to shutter their Oregon chipset fab and open up a FAB in China is not a one-time event but the start of a trend. In general it's easier for large companies to keep operations in the US; they can often extract tax concessions from local and state govenments as well as favorable tax treatment from the IRS.
This is typically not the case for small business. To stay compentitive I need to keep all my IC and board manufacturing overseas and the rest of my operations in the US to the absolute minimum. And if current trends continue I might have to move the HQ and the rest of the company overseas as well.
As for the role presidents play, FDR still has Obama beat in terms of absolutly the most destructive and moronic economic policies, but Obama's quickly gaining ground. Obama's cap and tax plan could end up being the the last nail in the coffin of American technological leadership.