There was a late 70's Canadian TV series called 'Starlost' featuring Keir Dullea, from '2001: A Space Odyssey'. Personally, I found that it dragged but the show did get a loyal following. Maybe I'll feel differently about it now, no longer being 10 years old ... :)
Starlost was significant in that its generation ship, which featured large dome-shaped botanical pods, is probably the most recycled image in TV and films!
One great series by John Varley that I read recently is Red Thunder (2nd and 3rd books are Red Lightening and Rolling Thunder), which involves a hollowed out asteroid turned into a Generation Ship. There's a lot of great stuff in this series.
Another that comes to mind is the Ringworld series (Larry Niven). The Ringworld itself could be considered a Generation Ship, but the Puppeteers also added drives to planets, and used them to escape the collapsing center of the galaxy! Great books.
There are also the four "Cities in Flight" novels by James Blish -- I remember reading these as a young lad, but I can;t really recall much about them...
...I seem to recall picking the firs tone up again about 10 years ago, but finding it not-so-interesting... but maybe I'm mistaken...
As we unveil EE Times’ 2015 Silicon 60 list, journalist & Silicon 60 researcher Peter Clarke hosts a conversation on startups in the electronics industry. Panelists Dan Armbrust (investment firm Silicon Catalyst), Andrew Kau (venture capital firm Walden International), and Stan Boland (successful serial entrepreneur, former CEO of Neul, Icera) join in the live debate.