yes, computing and vision impairment have been a particularly difficult task to tackle. No one has really come up with a good way of translating our GUI centered computing methods to an audio or tactile only experience. It is difficult to even wrap your mind around sometimes, just how different they are.
A relative of mine has been totally blind since she was nine years old. Over the past 41 years we've tried all sorts of high tech adaptive technology. It's mostly failed. GUIs have only made her long for the days of DOS when a serial text stream was easily navigated and converted to speech, which is also a serial data stream. Many blind adults are also poor, another challange for the designer. Among the major tech companies, Apple has done the best job of adapting a mainstream product for use by the blind community. There's room for improvement though.
Using our design skills to improve the life of another is, IMO, the greatest use to which we can put them Engineering out disability is one of the most direct and tangible ways of improving life that I can imagine.