If you aren't already aware of them, you might like to know about Clecos: http://www.rivetsonline.com/cleco.html which are to sheet-metal working what pins are to dress-making. They're a temporary fastener to hold 2 pieces aligned together while they are drilled or riveted.
If you want a lot of holes evenly spaced, an adjustable rivet spacer is a alternative http://www.aircraftspruce.com/catalog/topages/rivspacer.php?clickkey=6495 to a sheet of perf-board, but whether the extra expense is justified would depend on how important regularity and particular spacing is.
@ca94002...thanks for that.....I could easily have expanded this to two articles with all the other tools that commenters have given. I have a leather punch and a hand reamer as you describe, so I should not have forgotten about them. But then again, if I had covered everything I probably would not have got all these comments!
Drones are, in essence, flying autonomous vehicles. Pros and cons surrounding drones today might well foreshadow the debate over the development of self-driving cars. In the context of a strongly regulated aviation industry, "self-flying" drones pose a fresh challenge. How safe is it to fly drones in different environments? Should drones be required for visual line of sight – as are piloted airplanes? Join EE Times' Junko Yoshida as she moderates a panel of drone experts.