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HP's first lab-on-a-chip product targets DNA-related work
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Silicon Strategies


PALO ALTO, Calif. -- Lab-on-a-chip technology entered commercial reality today as Hewlett-Packard Co. introduced what it said was the first product of this type: the HP 2100 bioanalyzer for the integrated analysis of nucleic acids (the components of DNA).

The bioanalyzer is based LabChip technology from Caliper Technologies Corp.; the two Palo Alto-based companies announced their collaboration last year (see May 1998 story).

The HP 2100 marks a major step toward the development of a completely automated microscale laboratory, HP said. In this lab-on-a-chip, all sample preparation, fluid handling and biochemical analysis steps will be carried out within the confines of a microchip. Such chips comprise microchannels fabricated in glass, plastic or other substrates that create interconnected networks of fluid reservoirs and pathways.

Used together with various LabChip kits, the HP 2100 bioanalyzer improves the quality of nucleic acid analysis by integrating sample handling, separation, detection and digital data processing within a single, compact system architecture. The system is designed for use by molecular biologists and biochemists working with polymerase-chain-reaction (PCR) products, restriction enzyme digests or ribonucleic acid (RNA) preparations.

Researchers in the areas of disease and drug discovery currently face manual-processing bottlenecks during the analysis of nucleic acids. LabChip technology offers many benefits over existing manual gel electrophoresis products, including improved accuracy, faster analysis, and better reproducibility of results.

The HP 2100 bioanalyzer is initially available in the United States, Germany, the United Kingdom and Switzerland. The price of the complete system is $18,800.






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